Location, location, location! Put the arrow where it needs to be and I don't think you'll see any difference. Give me a particular bad shot scenario and I may prefer one over the other, but we never get the luxury of do-overs. Last week I killed a mature doe with a popular low-profile, 3 blade head. I wasn't at all happy after the shot. Complete pass-through, but too high (about 2/3rds of the way up the back) and too far back (just behind the last rib). The deer lay dead 75 yds. away when I immediately got down and still hunted straight to her. I've killed enough deer from this stand I knew where she would go, but I was surprised to recover this one. There's a "no-man's land" above the vitals and below the spine that deer usually recover from and I thought I was there. I back-trailed and found no blood other than where the deer lay. I never thought the lungs extended that far back, but I guess the 3-D's and diagrams are right. The largest buck I ever shot was with a two-blade and a shot I never intended to take, it was about 25 yds. and just outside my comfort zone. I was just going to draw and "count coup", but when I hit anchor the string just slipped through my fingers and hit right where I was looking. The deer was slightly quartering away and the arrow entered through the last rib just beside the spine and stopped in the off-side lung with no exit hole! I could see half the arrow sticking out of its back as it ran off and I was sick. That deer went over 300 yds, but from where it was standing, there was never a moment where I couldn't see blood trail. It looked like someone went down through the woods with a garden sprayer. Every time the deer exhaled it was coating the standing vegetation and leaves with a bright pink mist. How it went that far I have no idea. I probably didn't deserve to recover either of them, but I don't "look a gift deer in the mouth". My point is, I don't think if you swapped those two heads it would have made an iota's difference in either case!