Well, my 2 cents is if I were going to shoot a Simmons, I'd shoot the glue-on Tiger Shark. A screw-in Tree Shark is the only head I've ever had fold-up on me after a miss on game.
And though people 'gush' about the blood trails they leave, I think blood trails are more about where you hit than what you hit with.
A Simmmons is going to be trickier to sharpen, so if you're "sharpening challenged", you may want a more conventional head like the Eskimo or Delta or Magnus I. Personally, I've been very impressed by the Eclipse heads (especially the 145), and the deer I shot this season with a 4 blade Stinger left a monster blood trail.
You say "about 50" pounds, so I'll assume high 40's since lots of us short draw in hunting situations, so I'd stay away from the Tree Shark.
By the way, Simmons may be a good head, but Zwickey's are great heads. And there are hundreds of thousands of animals to back that up.