I'm pretty much with Jason. I like to set up all my bows for hunting, with as heavy a draw weight and as heavy an arrow as I can manage well. (Though, I do have a few bows that didn't make weight and are in the high 40's to mid 50's.) I'm not interested in scores, per say. I just want to be able to accurately shoot heavy gear that will slap monkey snot out of anything I encounter.
For a couple rounds of arrows, I really don't see a difference in accuracy between light and heavy setups. It's only when I start shooting repeated ends at the butts where fatigue takes its toll.