Imho, it all depends on your bow weight, and whether you are shooting from the ground or a gree, and your accuracy/distance of shot.
I've had 100% success on this angle, but I don't do it often. I shoot pretty heavy #, mid 60#s, and I shoot from the ground. At that ground level angle, if the arrow misses the juglar, it takes out the heart, lungs, liver, or diaphragm or all the above and leaves excellent blood trails and quick death. However, I absolutely would not take this shot from an elevated stand, using a light weight bow, or if the deer was watching me and could jump at the shot. Then it's too risky.