Do it in the winter for one. Chiggers suck...and hurt!
But I learned several years ago, if not decades ago, how to go through briars easily and without too many pricks on your skin.
If you have one (two are better) small manageable log(s) or landscape timber(s) you can take it and drop it across the brairs. I typically use one about 8 feet long and weighing in about 30-50 pounds, depending on the wood used. (when timber companies leave there are many of these logs lying about) This will press down the briars and you can walk on the timber to the end of it. Pick it up and drop it two or three times to widen your path. Walk the log as you progress. Leap frogging the log to beat down the brairs. Nippers or a machete help tame the creepers that hang out and over your path as you leap along.
In my area of NC we have many areas that are clear cut by timber companies. Within a year or two the briars take over. I can get through briars without too much headache or sticks from the thorns by using this method.
Now's the time to do it- Before the chiggers and ticks come back out and while we're planning next year's hunts.
I don't own an ATV, so driving over the brairs is not an option for me. I have to use the good ol' feet and boots.