ummm...what they said.
Seriously though, I shot a deer with almost exactly the same set up as what your talking about last year(Muzzy three blade 125 grain, overall arrow weight about 425 grains and a 45lb bow). Unfortunately, the shot was a little off and I did not get much penetration with that set up. I am switching to a two blade Simmons or Magnus broadhead this year and adding a 100 grain brass insert up front to inrease arrow weight.
Incidentally I saw the same deer several weeks later (non-typical rack)and he looked fine from what I could tell, Thank God.
Charlie