I agree, 75 grains is a big jump without double checking the bow tune and probably going to a stiffer shaft.
What may happen with the current shafts is that you might not see a major flight change at normal hunting distances. But it could be that(assuming the bow is tuned with the 125 grain heads)you maybe relying on the fletchings to stabilize the arrow with the additioanal weight up front, which is a good thing, but it may not be optimal.
If it were me, I'd check and also be open to a different shaft before considering the 75 grain jump.