Norman, there are plenty of deer on the refuge, and the south end is probably the best. It is the oldest unit of the refuge. You're from Louisana, so you know the type of territory, mostly oaks, and cypress. There are a lot of oxbow lakes and sloughs.
Come up through DeWitt going toward St. Charles on highway 1 and go into the Ethel area. There have been a lot of nice bucks come out of there. I have seen a good many deer around Wolf lake. There are plenty of places to camp. You can use a boat to get farther in, and there are ATV trails. Having said that, there are plenty of place to hunt from the gravel roads. The place is huge. There is a new visitor center at St. Charles. It is worth visiting, too.
You have to have a brochure to hunt on the refuge. It has the rules and a map on it. You can get one free at all main entrances to the refuge, but you need one before you go, so you can look the thing over. You should be able to get one from the web sites Joe listed. If not, I will get you one and send to you if you like.
As far as 150 class bucks: They're there, but I really couldn't tell you the odds. I've seen some big ole boys come out of that place.
As Joe said, there is a modern gun hunt and a muzzle loader hunt. You have to be drawn for a permit to hunt then. The rest of the time, just the brochure.
Oh, bring your binoculars. They are really into looking for the Ivory-bill woodpecker there. And if you hunt enough you are sure to see a black bear, too.