All else being equal, the first set up does have advantages, especially on big hogs. But shot placement is key, so accuracy it a big factor as well.
Tippit shoots bows more similar to your 2nd set up, and has killed one of those VW's with it on the Bacon Strip. So it can be done.
The good news is that you shouldn't really have to worry about 25 yard shots. The stand set ups down there should give you great chances at 15 yards or less. If you are confident in your accuracy at that range with the heavier bow that is the one I would choose.