Does your wife intend to find a job? If so, you gotta really keep that in mind. While northern Michigan is beautiful, finding higher wage jobs can be difficult. On top of it, with all the retired folks on pensions bailing for no/low tax states and/or warmer weather and the new auto workers making a fraction, northern Michigan could be a difficult place to sell a house in some area's if you decide to buy, since so many seasonal places are for sale. Right around my land, many seasonal places that were for sale in 2009 are still sitting there.
If you like to fish or duck hunt and don't mind traffic and the hustle and bustle, SE Detroit can actually be OK, as long as you're away from Detroit and the inner ring of suburbs, that now are no place to move to.
Port Huron has a station. You're close to Lake St. Clair, maybe the best fishing in the country, there's world class duck hunting and Canada for bear isn't far. For deer, you'd need to do legwork to find private ground there, but you're only a couple hours drive from 1,000,000's of public acres, although that deer hunting is also fairly spotty unless you do lots of homework and scouting.
As far as northern Michigan, the Frankfort, Ludington and Frankfort posts would be really nice, if your wife is stay at home or has a skill for a higher wage job. If she can work at a hospital or get into management of a resort or golf course, you can do well.
The UP posts would be beautiful for the 6 weeks of Spring, Summer and Fall, but while snow is fine, I don't want to live in feet of it from November to late April. LOL