I'm assuming you are only shooting fletched arrows with field points.You didn't mention any bare shaft or other tuning.Fletching will hide a multitude of tuning discrepancies.A fletched,field point arrow might appear to the eye to be flying well but if it isn't truly tuned,the broadhead version won't impact to the same place as the field points.Flight could also be very erratic and that also squanders a lot of your bow's energy which can drastically affect penetration.
2216's are supposed to be spined for 71#-80# bows.I suspect if you strip the feathers off one,you will see problems with flight.