Had to imagine much of a difference in performance in your first three setup if tuned. I would imagine with a 300 grain head you would have some improved penetration, but getting them to tune would likely be in issue. Haven't been hunting elk with a trad bow, but from what I hear it isn't uncommon to be shooting some longer distances, where trajectory can have an effect. I think I would stick with the setup that is tuned with the 175 grain heads, but it wouldn't be difficult to tune up to 225 grain heads if you have a little room to cut the shafts down a little. One way or another, good luck on your hunt.