I shoot 5" Vanes off my toothbrush rest. I can get full clearance with the right nock rotation.
On a metal handle that is cut so far past center it takes a thicker piece of leather to build it out to center shot. I built one on my buddies DAS and we had to really build it out.
That style of flipper rest gives great arrow clearance, but lack in the durability department. Yes it will work, but for hunting you can get the arm hung on something and the rest is done.
You could actually shoot the button with the toothbrush rest.