The only mixing I'll do is using B-55 in the loops, where it's just taking up space and not bearing any load.
Scott is right--they will have different rates of stretch and creep, so the stronger material is carrying the load. The weaker material is just adding weight, and maybe dampening sound.
Mike Treadaway uses a string that is part HMPE and part Dacron, but he uses enough of the HMPE material to carry the load. The Dacron is just a built in silencer. He said he likes them because they are quieter.
Personally I wouldn't suggest it and I won't sell a string like that. Too risky IMO.
Chad