Absolutely! The big bucks of any given area will rarely use the easily seen trails, but rather skirt said trails and scent check them, especially this time of the year...
Their trails can be identified but are much more subtle then the blatant trails used by does... That is one of the "secrets" to year in year out harvesting of mature bucks... IMO...
With experience one finds these things out... Most set up on the blatant trails and are tempted with does and lesser bucks that actually use these trails... If and when a mature buck is encountered they are in "their" trails and don't present themselves classically... One needs to find the subtle trails around the blatant trails and set up on them rather then the blatant trails...
If you are after meat, setup on the blatant trails... You will have better luck getting "a" deer, but if you are after a mature buck find the trails within the trails and give yourself the best chance at that mature buck!