I've used 2, 3, and 4 blades to take game. All work as long as I do my part. But, with that being said, I like 3 blade heads the best.
Not only 3 blades, but big 3 blades... Big Jim Big 3, VPA 1 1/4" 250 grain, Snuffer 160 with 100 gr insert... I've used Woodsmans, Razorcaps, and standard VPA, but with the #'age I shoot I like to do as much damage on the way through as I can... Even 2 and 4 blades are big... Zwickey Delta, Magnus 1, Centaur Big Game and Battle Axe, Silverflame DS...
Big wide holes are the norm, putting a lot of blood on the ground. But, blood trails usually are not necessary as they usually fall in sight...