A bow should perform similar with one lam or 4 as the distance between the glass is the same.
You could have issues with durability with a single lam as if there is a weak spot in the lam then the whole limb is weak. Multiple lams are like a sheet of plywood and stronger, more durable.
Dave mentioned that he had a couple bows with a core lam and 2 veneers. I'm guessing the veneers are not super thin like under .025. They are probably thicker, thus he has a 3 lam bow. Veneers count in your lamination stack, either way.
In a bow with two veneers and one core, you would have 4 glue joints holding the limb together. (or more if you have more core lams, etc.) In a bow with only one lam total you would only have 2 glue joints holding the limb together. I'd rather distribute the stress among 4 or more glue joints myself.
Also worth mentioning here is the bond between the glass to lam is not nearly as strong as the bond between lam to lam (wood to wood).
Just my ramblings on Christmas Eve as I'm home with a sick kid.
Chad