Pdk, chupa and the rest all threw in some good advice. I've shot bows all the way to 105# and I tell you, once you get into the 80's and above you'd better be doing some serious focused training to stay on top of it and not hurt yourself. Bow length and type is a big factor. Shooting a 76" 105#@32 bamboo backed English longbow with a little stringfollow is WAY easier than a 69" glass 94@29 straight or backset Hill Style that is for dang sure. The big long ELB lets you really lay your body in the bow as the old English used to say. Its amazing how much leverage increased bow length gives you at higher draw weights too. I actually became pretty decent shooting the big warbow with broadheads on 33" poplar arrows at 20 yds...I had plans of hunting with it, but the setup proved too cumbersome and I shelved that plan for the time being. The 94@29 Hill was a beast. I also had a 105@30" 69" Hill as well, also a monster. Bows of those kind of poundages take a high degree of dedication and discipline to shoot with any measure of control. You need to train drawing the bow and holding on non-shooting days, shoot it, cross train with weights and calisthenics like pull ups, and also give your body time to rest. You can pull a muscle or strain a ligament/tendon and develop tendonitis real easy if you get cocky and overdo it and do too much too fast. It pays to work up in poundage, and me I'd want a bow in the 70's at least to have some "light days" in between when I was shooting the 100#er. I've found that I can be a little more lax with anything 80's or less. That's my comfort zone. Once I hit the 90's on the glass Hill I realized it was a whole new ball game. I've since taken a break from heavies. My last bow was the 94@29 Hill. I think I may try an 84@29 next time and know that I can play around a bit more and not have to be so systematic and consistent with the drawing and shooting.
The hardest part honestly is building a decent tunable arrow for these monsters. There are options out there, but to get a heavy enough stiff enough shaft and enough FOC can be a little chore, and it can cost a bit too depending on what you go with.
Modern bows are so efficient that shooting these high poundages is more for enjoyment than any real practical use anyway. No need to hunt a rhino with a 100# Hill when a 75-80# hotrod recurve or hybrid longbow will do the job as good or better.