There are tons of variables to consider. You may have to swap arrows or point weight when changing to a different string. Will it be due to an performance difference? Comparing apples to apples, if you pick up 5 fps that is huge. Most people's release will vary about that much.
If you change silencers/silencer placement; if you swap from a glove to a tab or vice-versa; if you change nocks or serving size; if you change your brace height...all of these and more can affect arrow spine.
The only way to know if you will need different arrows is to try and see. The better you tune and the better/more consistent your release, the less chance you will need different arrows.
To check performance difference, shoot through a chronograph. That's usually an eye-opener for those who haven't done it.