I think there is no better broadhead design for structural integrity when passing through flesh and small bones. However, Ashby's conclusions that, on heavy animals, hitting large bones is pretty unavoidable, mean that elk size and up I will go to a single-bevel.
I boil down his findings as implying that a 3-blade such as the VPA (the best 3-blade on the market IMO) would kill X out of 100 animals on "good" shots; however, the single bevel would kill every one of those same X animals on the same shots, plus another amount Y. In other words, there is no downside to using the single-bevel on large, heavy game.