Two things of major importance that affect penetration are arrow weight and arrow flight.
The first factor is arrow weight. More weight = more penetration. As to your question, Dr. Ashby did studies a few years ago where he concluded that weight forward resulted in greater penetration than a more even distribution of weight. It is interesting to speculate on the physics of arrow flight, but he did exhaustive tests, and until we have better evidence, most bowhunters rely on his results.
The second question has to do with arrow flight. If an arrow hits an animal and the nock isn't directly in the line of force, if the arrow is porpoising or fishtailing, for example, the shaft will deflect away from the line of force, dissipating energy away from penetration. Optimal arrow flight and penetration are achieved when the arrows are properly tuned to the bow and archer. If an arrow is properly tuned so that a bare shaft flies true, then weight distribution for that particular arrow is irrelevant: tuned is tuned. I think some people have problems with EFOC because they try to get heavy heads to fly straight with weak shafts, but that is no different from anyone who tries to get mismatched equipment to work as they wish it would.
As far as the angle of attack that an arrow hits an animal, if one arrow hits an animal at a 45 degree angle, and another arrow hits an animal at a 90 degree angle, penetration will be unaffected by those angles as long as the arrows are properly tuned and the direction of force is the same as the angle of attack.
What people do worry about, validly in my opinion, is the tradeoff between using a heavy arrow and a lighter arrow, since the trajectory of any heavy arrow, EFOC or not, will be more curved than a lighter arrow shot from the same bow. This makes it easier to miss or wound an animal. Other people would say that the flatter trajectory of a lighter arrow makes it more likely that longer shots will be taken, leading to just as many missed or wounded animals. We're not likely to settle that argument here.